Breast cancer remains a major medical challenge, particularly due to its high recurrence rates, even after surgery and targeted therapies. Around 70% of patients may experience local, regional, or distant recurrence.

In this context, oleocanthal, a natural phenolic compound in extra virgin olive oil, has attracted scientific interest. Siddique and colleagues investigated whether oleocanthal could prevent or reduce breast cancer recurrence in experimental mouse models.

READ ALSO: THE ACTION OF OLEOCANTHAL AGAINST BREAST CANCER


The findings were promising:

-Daily oral administration of oleocanthal reduced tumor recurrence.
-In triple-negative breast cancer (TNBC), oleocanthal did not completely prevent recurrence, but significantly slowed tumor regrowth.
-Treated animals showed reduced CA 15-3 levels, increased E-cadherin expression, and decreased vimentin levels.
-Oleocanthal also lowered activation of MET and HER2 receptors.

This study provides the first evidence that oral oleocanthal treatment can suppress breast cancer recurrence in animal models, opening new perspectives for therapies based on natural compounds.

See the publication...