OLEACEIN HAS ANTI-CANCER PROPERTIES AGAINST NEUROBLASTOMA CELLS
Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells.
The aim of this research was to study the molecular mechanisms underlying the antiproliferative and anti-metastatic capacity of oleacein in the SH-SY5Y human neuroblastoma cell line. Cirmi and his partners, demonstrated that oleacein is able to reduce the proliferation of the SH-SY5Y cells by blocking the cell cycle in the S phase and inducing apoptotic cell death through the increase in both Bax and p53 as well as a reduction in the Bcl-2 expression and STAT3 phosphorylation. Moreover, oleacein caused reduction in the SH-SY5Y cell adhesion and migration.
Overall, these findings indicate that oleacein exerts anti-cancer effects against neuroblastoma cells, suggesting a promising role as a candidate against this type of cancer.