A recent study by Mete and colleagues investigated the neuroprotective properties of oleocanthal – a powerful phenolic compound found in extra virgin olive oil – in cases of traumatic brain injury (TBI).

TBI consists of two distinct phases:

-Primary injury, which occurs at the moment of impact.
-Secondary injury, where inflammation and oxidative stress continue to damage brain tissue.

The researchers focused on the secondary phase, where many treatments have been tested in the past with limited success.

What the scientists did:
In an experimental mouse model, different doses of oleocanthal were administered after TBI. Brain tissue and blood samples were then analyzed using histopathological and biochemical methods.

Key findings:
✔️Higher doses of oleocanthal significantly reduced oxidative stress levels.
✔️Treated groups showed less apoptosis (cell death) and healthier neuronal structures.
✔️The most protective effect was observed with 30 mg/kg of oleocanthal.

✅ Conclusion:
Oleocanthal appears to act as a natural neuroprotective agent, reducing oxidative stress and apoptosis after traumatic brain injury.

Although this research is still in an early stage (animal studies), the findings open the door for future studies and potential therapeutic applications in humans.


Fig. Effects of the EVOO polyphenols on the transforming ability of HER2.


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