THE ROLE OF OLEOCANTHAL IN BREAST AND PROSTATE CANCER
Oleocanthal as a cMet inhibitor for the control of metastatic breast and prostate cancers
Oleocanthal is a naturally occurring minor secoiridoid isolated from extra virgin olive oil, which showed potent anti-inflammatory activity. In the study of Enagar et al., Computer Assisted Molecular Design (CAMD) identified oleocanthal as a potential virtual cMet inhibitor hit. In this study oleocanthal inhibited the proliferation, migration, and invasion of the epithelial human breast and prostate cancer cell lines with an IC(50) of 4.47μΜ. Moreover, oleocanthal inhibited the phosphorylation of cMet kinase in vitro, with an IC (50) value of 4.8μM. These results show that oleocanthal and EVOO can have potential therapeutic use for the control of cMet-dependent malignancies.
In this study oleocanthal inhibited the proliferation, migration, and invasion of the epithelial human breast and prostate cancer cell lines.